Please cite:
Dimitra Karagkouni, Maria D. Paraskevopoulou, Serafeim Chatzopoulos, Ioannis S. Vlachos, Spyros Tastsoglou, Ilias Kanellos, Dimitris Papadimitriou, Ioannis Kavakiotis, Sofia Maniou, Giorgos Skoufos, Thanasis Vergoulis, Theodore Dalamagas, Artemis G. Hatzigeorgiou; DIANA-TarBase v8: a decade-long collection of experimentally supported miRNA–gene interactions, Nucleic Acids Research, gkx1141, https://doi.org/10.1093/nar/gkx1141
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hsa-miR-221-3p


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Interactions: 1278, Experiments: (low: , high: , unknown: ) Cell lines: , Tissues: , Publications:
Gene name miRNA name Experiments
throughput
Publications Cell lines Tissues Pred. Score
CDKN1B hsa-miR-221-3p low: 5 high: 8 9 8 6 0.984
Low-throughput experiments (5 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Kim Young-Kook et al. 2009 RP Gastric SNU638 SNU638 N/A
Location Method Result Regulation Validation Type Source
chr12:12721288-12721321 Luciferase Reporter Assay POSITIVE DIRECT TarBase 8.0
chr12:12721215-12721248 Luciferase Reporter Assay POSITIVE DIRECT TarBase 8.0
Kim Young-Kook et al. 2009 RP Gastric N/A HELA N/A
Location Method Result Regulation Validation Type Source
chr12:12721288-12721321 Luciferase Reporter Assay POSITIVE DIRECT TarBase 8.0
chr12:12721215-12721248 Luciferase Reporter Assay POSITIVE DIRECT TarBase 8.0
Carlos le Sage et al. 2007 RP Mammary Gland MCF7 MCF7 N/A
Location Method Result Regulation Validation Type Source
chr12:12721054-12722332 Luciferase Reporter Assay POSITIVE DIRECT TarBase 8.0
High-throughput experiments (8 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Grosswendt S et al. 2014 IP Kidney HEK293 N/A N/A
Location Method Result Regulation Validation Type Source
chr12:12721287-12721310 Chimeric fragments POSITIVE DIRECT TarBase 8.0
Xue Y et al. 2013 IP Cervix HELA N/A Hela cells were treated with control shRNA.
Location Method Result Regulation Validation Type Source
chr12:12721210-12721234 HITS-CLIP POSITIVE DIRECT TarBase 7.0
Skalsky Rebecca L. et al. 2012 IP N/A LCL35 N/A N/A
Location Method Result Regulation Validation Type Source
chr12:12721210-12721234 PAR-CLIP POSITIVE DIRECT TarBase 7.0
Sebastian Memczak et al. 2013 IP Kidney HEK293 N/A N/A
Location Method Result Regulation Validation Type Source
chr12:12721288-12721307 PAR-CLIP POSITIVE DIRECT TarBase 7.0
Meiyun Fan et al. 2013 IP Mammary Gland MDAMB231 N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN AGO-IP POSITIVE INDIRECT TarBase 7.0
Kishore S et al. 2011 IP Kidney HEK293 N/A mild MNase digestion
Location Method Result Regulation Validation Type Source
chr12:12721288-12721307 PAR-CLIP POSITIVE DIRECT TarBase 7.0
chr12:12721288-12721307 PAR-CLIP POSITIVE DIRECT TarBase 7.0
Kameswaran V et al. 2014 IP Pancreas BETA Cells N/A N/A
Location Method Result Regulation Validation Type Source
chr12:12721210-12721234 HITS-CLIP POSITIVE DIRECT TarBase 7.0
PTEN hsa-miR-221-3p low: 5 high: 0 1 4 2 0.755
Low-throughput experiments (5 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Michela Garofalo et al. 2009 WB Liver SKHEP1 N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Western Blot POSITIVE INDIRECT TarBase 7.0
Michela Garofalo et al. 2009 WB Lung H460 N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Western Blot POSITIVE INDIRECT TarBase 7.0
Michela Garofalo et al. 2009 WB qP Lung CALU1 N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Western Blot POSITIVE INDIRECT TarBase 7.0
UNKNOWN qPCR POSITIVE INDIRECT TarBase 7.0
Michela Garofalo et al. 2009 RP Lung NSCLC MEG01 N/A
Location Method Result Regulation Validation Type Source
chr10:87965657-87965693 Luciferase Reporter Assay POSITIVE DIRECT TarBase 7.0
FMR1 hsa-miR-221-3p low: 4 high: 4 2 3 2 -
Low-throughput experiments (3 positive, 1 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Samantha Zongaro et al. 2013 WB qP Brain MPN10 5510 N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Western Blot NEGATIVE INDIRECT TarBase 7.0
UNKNOWN qPCR POSITIVE INDIRECT TarBase 7.0
Samantha Zongaro et al. 2013 qP Cervix HELA N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN qPCR POSITIVE INDIRECT TarBase 7.0
Samantha Zongaro et al. 2013 RP Cervix HELA HELA N/A
Location Method Result Regulation Validation Type Source
chrX:147949430-147949542 Luciferase Reporter Assay POSITIVE DIRECT TarBase 7.0
High-throughput experiments (4 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Boudreau RL et al. 2014 IP Brain N/A N/A N/A
Location Method Result Regulation Validation Type Source
chrX:147949455-147949481 HITS-CLIP POSITIVE DIRECT TarBase 8.0
chrX:147949455-147949481 HITS-CLIP POSITIVE DIRECT TarBase 8.0
chrX:147949455-147949481 HITS-CLIP POSITIVE DIRECT TarBase 8.0
chrX:147949455-147949481 HITS-CLIP POSITIVE DIRECT TarBase 8.0
CTCF hsa-miR-221-3p low: 3 high: 3 4 5 3 -
Low-throughput experiments (3 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Lupini Laura et al. 2013 RP Liver HEPG2 HEPG2 N/A
Location Method Result Regulation Validation Type Source
chr16:67638186-67639117 Luciferase Reporter Assay POSITIVE DIRECT TarBase 8.0
Lupini Laura et al. 2013 RP Liver SNU398 SNU398 N/A
Location Method Result Regulation Validation Type Source
chr16:67638186-67639117 Luciferase Reporter Assay POSITIVE DIRECT TarBase 8.0
Lupini Laura et al. 2013 RP Kidney HEK293 HEK293 N/A
Location Method Result Regulation Validation Type Source
chr16:67638186-67639117 Luciferase Reporter Assay POSITIVE DIRECT TarBase 8.0
High-throughput experiments (3 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Kishore S et al. 2011 IP Kidney HEK293 N/A mild MNase digestion
Location Method Result Regulation Validation Type Source
chr16:67638711-67638731 PAR-CLIP POSITIVE DIRECT TarBase 7.0
Karginov FV et al. 2013 IP Kidney 293S N/A treatment: emetine
Location Method Result Regulation Validation Type Source
chr16:67638558-67638583 HITS-CLIP POSITIVE DIRECT TarBase 7.0
Hafner M. et al. 2010 IP Kidney HEK293 N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN PAR-CLIP POSITIVE DIRECT TarBase 6.0
Other Databases
Publication Methods Tissue Cell line Tested cell line Exp. condition
Lupini Laura et al. 2013 O N/A N/A N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Other UNKNOWN UNKNOWN miRTarBase
WEE1 hsa-miR-221-3p low: 3 high: 2 3 5 3 0.492
Low-throughput experiments (3 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Lupini Laura et al. 2013 RP Liver HEPG2 HEPG2 N/A
Location Method Result Regulation Validation Type Source
chr11:9589164-9589187 Luciferase Reporter Assay POSITIVE DIRECT TarBase 8.0
Lupini Laura et al. 2013 RP Liver SNU398 SNU398 N/A
Location Method Result Regulation Validation Type Source
chr11:9589164-9589187 Luciferase Reporter Assay POSITIVE DIRECT TarBase 8.0
Lupini Laura et al. 2013 RP Kidney HEK293 HEK293 N/A
Location Method Result Regulation Validation Type Source
chr11:9589164-9589187 Luciferase Reporter Assay POSITIVE DIRECT TarBase 8.0
High-throughput experiments (2 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Karginov FV et al. 2013 IP Kidney 293S N/A treatment:hippuristanol
Location Method Result Regulation Validation Type Source
chr11:9589169-9589185 HITS-CLIP POSITIVE DIRECT TarBase 7.0
Karginov FV et al. 2013 IP Kidney 293S N/A treatment: arsenite
Location Method Result Regulation Validation Type Source
chr11:9589169-9589185 HITS-CLIP POSITIVE DIRECT TarBase 7.0
Other Databases
Publication Methods Tissue Cell line Tested cell line Exp. condition
Hafner M. et al. 2010 O N/A N/A N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Other UNKNOWN UNKNOWN miRTarBase
Lupini Laura et al. 2013 O N/A N/A N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Other UNKNOWN UNKNOWN miRTarBase
BNIP3L hsa-miR-221-3p low: 3 high: 2 2 1 3 0.785
Low-throughput experiments (3 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Pascal Pineau et al. 2010 WB qP N/A N/A N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Western Blot POSITIVE INDIRECT TarBase 6.0
UNKNOWN qPCR POSITIVE INDIRECT TarBase 6.0
Pascal Pineau et al. 2010 RP Breast Cancerous Tissues N/A HEK293T N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Luciferase Reporter Assay POSITIVE DIRECT TarBase 6.0
High-throughput experiments (2 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Boudreau RL et al. 2014 IP Brain N/A N/A N/A
Location Method Result Regulation Validation Type Source
chr8:26412032-26412051 HITS-CLIP POSITIVE DIRECT TarBase 8.0
Pascal Pineau et al. 2010 MA N/A N/A N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Microarrays POSITIVE INDIRECT TarBase 6.0
Other Databases
Publication Methods Tissue Cell line Tested cell line Exp. condition
Pascal Pineau et al. 2010 O N/A N/A N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Other UNKNOWN UNKNOWN miRTarBase
ANXA1 hsa-miR-221-3p low: 3 high: 0 1 4 3 -
Low-throughput experiments (3 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Lupini Laura et al. 2013 RP Liver HEPG2 HEPG2 N/A
Location Method Result Regulation Validation Type Source
chr9:73170128-73170364 Luciferase Reporter Assay POSITIVE DIRECT TarBase 8.0
Lupini Laura et al. 2013 RP Liver SNU398 SNU398 N/A
Location Method Result Regulation Validation Type Source
chr9:73170128-73170364 Luciferase Reporter Assay POSITIVE DIRECT TarBase 8.0
Lupini Laura et al. 2013 RP Kidney HEK293 HEK293 N/A
Location Method Result Regulation Validation Type Source
chr9:73170128-73170364 Luciferase Reporter Assay POSITIVE DIRECT TarBase 8.0
Other Databases
Publication Methods Tissue Cell line Tested cell line Exp. condition
Lupini Laura et al. 2013 O N/A N/A N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Other UNKNOWN UNKNOWN miRTarBase
RB1 hsa-miR-221-3p low: 3 high: 0 1 4 3 -
Low-throughput experiments (3 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Lupini Laura et al. 2013 RP Liver HEPG2 HEPG2 N/A
Location Method Result Regulation Validation Type Source
chr13:48480093-48481082 Luciferase Reporter Assay POSITIVE DIRECT TarBase 8.0
Lupini Laura et al. 2013 RP Liver SNU398 SNU398 N/A
Location Method Result Regulation Validation Type Source
chr13:48480093-48481082 Luciferase Reporter Assay POSITIVE DIRECT TarBase 8.0
Lupini Laura et al. 2013 RP Kidney HEK293 HEK293 N/A
Location Method Result Regulation Validation Type Source
chr13:48480093-48481082 Luciferase Reporter Assay POSITIVE DIRECT TarBase 8.0
Other Databases
Publication Methods Tissue Cell line Tested cell line Exp. condition
Lupini Laura et al. 2013 O N/A N/A N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Other UNKNOWN UNKNOWN miRTarBase
GJA1 hsa-miR-221-3p low: 3 high: 0 1 2 2 -
Low-throughput experiments (3 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Jianwei Hao et al. 2012 RP Brain U251 U251 N/A
Location Method Result Regulation Validation Type Source
chr6:121449589-121449689 Luciferase Reporter Assay POSITIVE DIRECT TarBase 7.0
Jianwei Hao et al. 2012 WB O Brain U251 N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Western Blot POSITIVE INDIRECT TarBase 7.0
UNKNOWN Immunofluorescence POSITIVE INDIRECT TarBase 7.0
Other Databases
Publication Methods Tissue Cell line Tested cell line Exp. condition
Jianwei Hao et al. 2012 O N/A N/A N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Other UNKNOWN UNKNOWN miRTarBase
APAF1 hsa-miR-221-3p low: 3 high: 0 1 3 2 -
Low-throughput experiments (3 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Lupini Laura et al. 2013 RP Liver HEPG2 HEPG2 N/A
Location Method Result Regulation Validation Type Source
chr12:98732439-98733160 Luciferase Reporter Assay POSITIVE DIRECT TarBase 8.0
Lupini Laura et al. 2013 RP Liver SNU398 SNU398 N/A
Location Method Result Regulation Validation Type Source
chr12:98732439-98733160 Luciferase Reporter Assay POSITIVE DIRECT TarBase 8.0
Lupini Laura et al. 2013 RP Kidney HEK293 HEK293 N/A
Location Method Result Regulation Validation Type Source
chr12:98732439-98733160 Luciferase Reporter Assay POSITIVE DIRECT TarBase 8.0
FASLG hsa-miR-221-3p low: 3 high: 0 1 3 2 -
Low-throughput experiments (0 positive, 3 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Lupini Laura et al. 2013 RP Liver HEPG2 HEPG2 N/A
Location Method Result Regulation Validation Type Source
chr1:172666147-172666171 Luciferase Reporter Assay NEGATIVE DIRECT TarBase 8.0
Lupini Laura et al. 2013 RP Liver SNU398 SNU398 N/A
Location Method Result Regulation Validation Type Source
chr1:172666147-172666171 Luciferase Reporter Assay NEGATIVE DIRECT TarBase 8.0
Lupini Laura et al. 2013 RP Kidney HEK293 HEK293 N/A
Location Method Result Regulation Validation Type Source
chr1:172666147-172666171 Luciferase Reporter Assay NEGATIVE DIRECT TarBase 8.0
ZEB2 hsa-miR-221-3p low: 3 high: 0 1 2 2 -
Low-throughput experiments (3 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Yun Chen et al. 2010 WB qP N/A N/A N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Western Blot POSITIVE INDIRECT TarBase 6.0
UNKNOWN qPCR POSITIVE INDIRECT TarBase 6.0
Yun Chen et al. 2010 RP Umbilical Vein HUVEC HUVEC N/A
Location Method Result Regulation Validation Type Source
chr2:144388016-144388057 Luciferase Reporter Assay POSITIVE DIRECT TarBase 6.0
CDKN1C hsa-miR-221-3p low: 2 high: 0 5 2 2 -
Low-throughput experiments (2 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Kim Young-Kook et al. 2009 RP Gastric SNU638 SNU638 N/A
Location Method Result Regulation Validation Type Source
chr11:2883815-2883848 Luciferase Reporter Assay POSITIVE DIRECT TarBase 8.0
Kim Young-Kook et al. 2009 RP Gastric N/A HELA N/A
Location Method Result Regulation Validation Type Source
chr11:2883815-2883848 Luciferase Reporter Assay POSITIVE DIRECT TarBase 8.0
Other Databases
Publication Methods Tissue Cell line Tested cell line Exp. condition
Pascal Pineau et al. 2010 O N/A N/A N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Other UNKNOWN UNKNOWN miRTarBase
Sun Kai et al. 2011 O N/A N/A N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Other UNKNOWN UNKNOWN miRTarBase
F Fornari et al. 2008 O N/A N/A N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Other UNKNOWN UNKNOWN miRTarBase
Kim Young-Kook et al. 2009 O N/A N/A N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Other UNKNOWN UNKNOWN miRTarBase
Ricardo Medina et al. 2008 O N/A N/A N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Other UNKNOWN UNKNOWN miRTarBase
TBK1 hsa-miR-221-3p low: 2 high: 1 1 1 2 -
Low-throughput experiments (2 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Pascal Pineau et al. 2010 WB N/A N/A N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Western Blot POSITIVE INDIRECT TarBase 6.0
Pascal Pineau et al. 2010 RP Breast Cancerous Tissues N/A HEK293T N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Luciferase Reporter Assay POSITIVE DIRECT TarBase 6.0
High-throughput experiments (1 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Pascal Pineau et al. 2010 MA N/A N/A N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Microarrays POSITIVE INDIRECT TarBase 6.0
Other Databases
Publication Methods Tissue Cell line Tested cell line Exp. condition
Pascal Pineau et al. 2010 O N/A N/A N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Other UNKNOWN UNKNOWN miRTarBase
DICER1 hsa-miR-221-3p low: 2 high: 0 1 2 2 0.551
Low-throughput experiments (2 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Dawn R Cochrane et al. 2010 WB Mammary Gland T47D N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Western Blot POSITIVE INDIRECT TarBase 7.0
Dawn R Cochrane et al. 2010 RP Uterus/Endometrium HEC50 HEC50 N/A
Location Method Result Regulation Validation Type Source
chr14:95087607-95087621 Luciferase Reporter Assay POSITIVE DIRECT TarBase 7.0
ETS2 hsa-miR-221-3p low: 2 high: 0 1 1 1 0.607
Low-throughput experiments (2 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Yu-Hsuan Wu et al. 2011 qP Skin HMEC1 N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN qPCR POSITIVE INDIRECT TarBase 7.0
Yu-Hsuan Wu et al. 2011 RP Skin HMEC1 HEK293T N/A
Location Method Result Regulation Validation Type Source
chr21:38823999-38824023 Luciferase Reporter Assay POSITIVE DIRECT TarBase 7.0
DVL2 hsa-miR-221-3p low: 2 high: 0 1 1 1 -
Low-throughput experiments (2 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Zheng C et al. 2011 WB qP N/A N/A N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Western Blot POSITIVE INDIRECT TarBase 6.0
UNKNOWN qPCR POSITIVE INDIRECT TarBase 6.0
ESR1 hsa-miR-221-3p low: 2 high: 0 1 1 1 -
Low-throughput experiments (1 positive, 1 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Dawn R Cochrane et al. 2010 RP RP Mammary Gland MCF7 MCF7 N/A
Location Method Result Regulation Validation Type Source
chr6:152101091-152101437 Luciferase Reporter Assay POSITIVE DIRECT TarBase 7.0
chr6:152102551-152103214 Luciferase Reporter Assay NEGATIVE DIRECT TarBase 7.0
GAX(hsa) hsa-miR-221-3p low: 2 high: 0 1 1 1 -
Low-throughput experiments (2 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Yun Chen et al. 2010 WB qP N/A N/A N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Western Blot POSITIVE INDIRECT TarBase 6.0
UNKNOWN qPCR POSITIVE INDIRECT TarBase 6.0
FOS hsa-miR-221-3p low: 1 high: 2 3 3 3 0.852
Low-throughput experiments (1 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Atsuhiko Ichimura et al. 2010 RP Kidney HEK293 HEK293 N/A
Location Method Result Regulation Validation Type Source
chr14:75281496-75281842 Luciferase Reporter Assay POSITIVE DIRECT TarBase 8.0
High-throughput experiments (2 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Kameswaran V et al. 2014 IP Pancreas BETA Cells N/A N/A
Location Method Result Regulation Validation Type Source
chr14:75281612-75281633 HITS-CLIP POSITIVE DIRECT TarBase 7.0
Balakrishnan I et al. 2014 IP Bone Marrow HMSC N/A N/A
Location Method Result Regulation Validation Type Source
chr14:75281612-75281633 HITS-CLIP POSITIVE DIRECT TarBase 7.0