Please cite:
Dimitra Karagkouni, Maria D. Paraskevopoulou, Serafeim Chatzopoulos, Ioannis S. Vlachos, Spyros Tastsoglou, Ilias Kanellos, Dimitris Papadimitriou, Ioannis Kavakiotis, Sofia Maniou, Giorgos Skoufos, Thanasis Vergoulis, Theodore Dalamagas, Artemis G. Hatzigeorgiou; DIANA-TarBase v8: a decade-long collection of experimentally supported miRNA–gene interactions, Nucleic Acids Research, gkx1141, https://doi.org/10.1093/nar/gkx1141
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hsa-miR-221-3p


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Interactions: 964, Experiments: (low: , high: , unknown: ) Cell lines: , Tissues: , Publications:
Gene name miRNA name Experiments
throughput
Publications Cell lines Tissues Pred. Score
CDKN1B hsa-miR-221-3p low: 5 high: 8 9 8 6 0.984
Low-throughput experiments (5 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Kim Young-Kook et al. 2009 RP Gastric SNU638 SNU638 N/A
Location Method Result Regulation Validation Type Source
chr12:12721288-12721321 Luciferase Reporter Assay POSITIVE DIRECT TarBase 8.0
chr12:12721215-12721248 Luciferase Reporter Assay POSITIVE DIRECT TarBase 8.0
Kim Young-Kook et al. 2009 RP Gastric N/A HELA N/A
Location Method Result Regulation Validation Type Source
chr12:12721288-12721321 Luciferase Reporter Assay POSITIVE DIRECT TarBase 8.0
chr12:12721215-12721248 Luciferase Reporter Assay POSITIVE DIRECT TarBase 8.0
Carlos le Sage et al. 2007 RP Mammary Gland MCF7 MCF7 N/A
Location Method Result Regulation Validation Type Source
chr12:12721054-12722332 Luciferase Reporter Assay POSITIVE DIRECT TarBase 8.0
High-throughput experiments (8 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Grosswendt S et al. 2014 IP Kidney HEK293 N/A N/A
Location Method Result Regulation Validation Type Source
chr12:12721287-12721310 Chimeric fragments POSITIVE DIRECT TarBase 8.0
Xue Y et al. 2013 IP Cervix HELA N/A Hela cells were treated with control shRNA.
Location Method Result Regulation Validation Type Source
chr12:12721210-12721234 HITS-CLIP POSITIVE DIRECT TarBase 7.0
Skalsky Rebecca L. et al. 2012 IP N/A LCL35 N/A N/A
Location Method Result Regulation Validation Type Source
chr12:12721210-12721234 PAR-CLIP POSITIVE DIRECT TarBase 7.0
Sebastian Memczak et al. 2013 IP Kidney HEK293 N/A N/A
Location Method Result Regulation Validation Type Source
chr12:12721288-12721307 PAR-CLIP POSITIVE DIRECT TarBase 7.0
Meiyun Fan et al. 2013 IP Mammary Gland MDAMB231 N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN AGO-IP POSITIVE INDIRECT TarBase 7.0
Kishore S et al. 2011 IP Kidney HEK293 N/A mild MNase digestion
Location Method Result Regulation Validation Type Source
chr12:12721288-12721307 PAR-CLIP POSITIVE DIRECT TarBase 7.0
chr12:12721288-12721307 PAR-CLIP POSITIVE DIRECT TarBase 7.0
Kameswaran V et al. 2014 IP Pancreas BETA Cells N/A N/A
Location Method Result Regulation Validation Type Source
chr12:12721210-12721234 HITS-CLIP POSITIVE DIRECT TarBase 7.0
PTEN hsa-miR-221-3p low: 5 high: 0 1 4 2 0.755
Low-throughput experiments (5 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Michela Garofalo et al. 2009 WB Liver SKHEP1 N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Western Blot POSITIVE INDIRECT TarBase 7.0
Michela Garofalo et al. 2009 WB Lung H460 N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Western Blot POSITIVE INDIRECT TarBase 7.0
Michela Garofalo et al. 2009 WB qP Lung CALU1 N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Western Blot POSITIVE INDIRECT TarBase 7.0
UNKNOWN qPCR POSITIVE INDIRECT TarBase 7.0
Michela Garofalo et al. 2009 RP Lung NSCLC MEG01 N/A
Location Method Result Regulation Validation Type Source
chr10:87965657-87965693 Luciferase Reporter Assay POSITIVE DIRECT TarBase 7.0
FMR1 hsa-miR-221-3p low: 4 high: 4 2 3 2 -
Low-throughput experiments (3 positive, 1 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Samantha Zongaro et al. 2013 WB qP Brain MPN10 5510 N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Western Blot NEGATIVE INDIRECT TarBase 7.0
UNKNOWN qPCR POSITIVE INDIRECT TarBase 7.0
Samantha Zongaro et al. 2013 qP Cervix HELA N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN qPCR POSITIVE INDIRECT TarBase 7.0
Samantha Zongaro et al. 2013 RP Cervix HELA HELA N/A
Location Method Result Regulation Validation Type Source
chrX:147949430-147949542 Luciferase Reporter Assay POSITIVE DIRECT TarBase 7.0
High-throughput experiments (4 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Boudreau RL et al. 2014 IP Brain N/A N/A N/A
Location Method Result Regulation Validation Type Source
chrX:147949455-147949481 HITS-CLIP POSITIVE DIRECT TarBase 8.0
chrX:147949455-147949481 HITS-CLIP POSITIVE DIRECT TarBase 8.0
chrX:147949455-147949481 HITS-CLIP POSITIVE DIRECT TarBase 8.0
chrX:147949455-147949481 HITS-CLIP POSITIVE DIRECT TarBase 8.0
CTCF hsa-miR-221-3p low: 3 high: 3 4 4 2 -
Low-throughput experiments (3 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Lupini Laura et al. 2013 RP Liver HEPG2 HEPG2 N/A
Location Method Result Regulation Validation Type Source
chr16:67638186-67639117 Luciferase Reporter Assay POSITIVE DIRECT TarBase 8.0
Lupini Laura et al. 2013 RP Liver SNU398 SNU398 N/A
Location Method Result Regulation Validation Type Source
chr16:67638186-67639117 Luciferase Reporter Assay POSITIVE DIRECT TarBase 8.0
Lupini Laura et al. 2013 RP Kidney HEK293 HEK293 N/A
Location Method Result Regulation Validation Type Source
chr16:67638186-67639117 Luciferase Reporter Assay POSITIVE DIRECT TarBase 8.0
High-throughput experiments (3 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Kishore S et al. 2011 IP Kidney HEK293 N/A mild MNase digestion
Location Method Result Regulation Validation Type Source
chr16:67638711-67638731 PAR-CLIP POSITIVE DIRECT TarBase 7.0
Karginov FV et al. 2013 IP Kidney 293S N/A treatment: emetine
Location Method Result Regulation Validation Type Source
chr16:67638558-67638583 HITS-CLIP POSITIVE DIRECT TarBase 7.0
Hafner M. et al. 2010 IP Kidney HEK293 N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN PAR-CLIP POSITIVE DIRECT TarBase 6.0
WEE1 hsa-miR-221-3p low: 3 high: 2 2 4 2 0.492
Low-throughput experiments (3 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Lupini Laura et al. 2013 RP Liver HEPG2 HEPG2 N/A
Location Method Result Regulation Validation Type Source
chr11:9589164-9589187 Luciferase Reporter Assay POSITIVE DIRECT TarBase 8.0
Lupini Laura et al. 2013 RP Liver SNU398 SNU398 N/A
Location Method Result Regulation Validation Type Source
chr11:9589164-9589187 Luciferase Reporter Assay POSITIVE DIRECT TarBase 8.0
Lupini Laura et al. 2013 RP Kidney HEK293 HEK293 N/A
Location Method Result Regulation Validation Type Source
chr11:9589164-9589187 Luciferase Reporter Assay POSITIVE DIRECT TarBase 8.0
High-throughput experiments (2 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Karginov FV et al. 2013 IP Kidney 293S N/A treatment:hippuristanol
Location Method Result Regulation Validation Type Source
chr11:9589169-9589185 HITS-CLIP POSITIVE DIRECT TarBase 7.0
Karginov FV et al. 2013 IP Kidney 293S N/A treatment: arsenite
Location Method Result Regulation Validation Type Source
chr11:9589169-9589185 HITS-CLIP POSITIVE DIRECT TarBase 7.0
BNIP3L hsa-miR-221-3p low: 3 high: 2 2 1 3 0.785
Low-throughput experiments (3 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Pascal Pineau et al. 2010 WB qP N/A N/A N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Western Blot POSITIVE INDIRECT TarBase 6.0
UNKNOWN qPCR POSITIVE INDIRECT TarBase 6.0
Pascal Pineau et al. 2010 RP Breast Cancerous Tissues N/A HEK293T N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Luciferase Reporter Assay POSITIVE DIRECT TarBase 6.0
High-throughput experiments (2 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Boudreau RL et al. 2014 IP Brain N/A N/A N/A
Location Method Result Regulation Validation Type Source
chr8:26412032-26412051 HITS-CLIP POSITIVE DIRECT TarBase 8.0
Pascal Pineau et al. 2010 MA N/A N/A N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Microarrays POSITIVE INDIRECT TarBase 6.0
ANXA1 hsa-miR-221-3p low: 3 high: 0 1 3 2 -
Low-throughput experiments (3 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Lupini Laura et al. 2013 RP Liver HEPG2 HEPG2 N/A
Location Method Result Regulation Validation Type Source
chr9:73170128-73170364 Luciferase Reporter Assay POSITIVE DIRECT TarBase 8.0
Lupini Laura et al. 2013 RP Liver SNU398 SNU398 N/A
Location Method Result Regulation Validation Type Source
chr9:73170128-73170364 Luciferase Reporter Assay POSITIVE DIRECT TarBase 8.0
Lupini Laura et al. 2013 RP Kidney HEK293 HEK293 N/A
Location Method Result Regulation Validation Type Source
chr9:73170128-73170364 Luciferase Reporter Assay POSITIVE DIRECT TarBase 8.0
RB1 hsa-miR-221-3p low: 3 high: 0 1 3 2 -
Low-throughput experiments (3 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Lupini Laura et al. 2013 RP Liver HEPG2 HEPG2 N/A
Location Method Result Regulation Validation Type Source
chr13:48480093-48481082 Luciferase Reporter Assay POSITIVE DIRECT TarBase 8.0
Lupini Laura et al. 2013 RP Liver SNU398 SNU398 N/A
Location Method Result Regulation Validation Type Source
chr13:48480093-48481082 Luciferase Reporter Assay POSITIVE DIRECT TarBase 8.0
Lupini Laura et al. 2013 RP Kidney HEK293 HEK293 N/A
Location Method Result Regulation Validation Type Source
chr13:48480093-48481082 Luciferase Reporter Assay POSITIVE DIRECT TarBase 8.0
GJA1 hsa-miR-221-3p low: 3 high: 0 1 1 1 -
Low-throughput experiments (3 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Jianwei Hao et al. 2012 RP Brain U251 U251 N/A
Location Method Result Regulation Validation Type Source
chr6:121449589-121449689 Luciferase Reporter Assay POSITIVE DIRECT TarBase 7.0
Jianwei Hao et al. 2012 WB O Brain U251 N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Western Blot POSITIVE INDIRECT TarBase 7.0
UNKNOWN Immunofluorescence POSITIVE INDIRECT TarBase 7.0
APAF1 hsa-miR-221-3p low: 3 high: 0 1 3 2 -
Low-throughput experiments (3 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Lupini Laura et al. 2013 RP Liver HEPG2 HEPG2 N/A
Location Method Result Regulation Validation Type Source
chr12:98732439-98733160 Luciferase Reporter Assay POSITIVE DIRECT TarBase 8.0
Lupini Laura et al. 2013 RP Liver SNU398 SNU398 N/A
Location Method Result Regulation Validation Type Source
chr12:98732439-98733160 Luciferase Reporter Assay POSITIVE DIRECT TarBase 8.0
Lupini Laura et al. 2013 RP Kidney HEK293 HEK293 N/A
Location Method Result Regulation Validation Type Source
chr12:98732439-98733160 Luciferase Reporter Assay POSITIVE DIRECT TarBase 8.0
FASLG hsa-miR-221-3p low: 3 high: 0 1 3 2 -
Low-throughput experiments (0 positive, 3 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Lupini Laura et al. 2013 RP Liver HEPG2 HEPG2 N/A
Location Method Result Regulation Validation Type Source
chr1:172666147-172666171 Luciferase Reporter Assay NEGATIVE DIRECT TarBase 8.0
Lupini Laura et al. 2013 RP Liver SNU398 SNU398 N/A
Location Method Result Regulation Validation Type Source
chr1:172666147-172666171 Luciferase Reporter Assay NEGATIVE DIRECT TarBase 8.0
Lupini Laura et al. 2013 RP Kidney HEK293 HEK293 N/A
Location Method Result Regulation Validation Type Source
chr1:172666147-172666171 Luciferase Reporter Assay NEGATIVE DIRECT TarBase 8.0
ZEB2 hsa-miR-221-3p low: 3 high: 0 1 2 2 -
Low-throughput experiments (3 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Yun Chen et al. 2010 WB qP N/A N/A N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Western Blot POSITIVE INDIRECT TarBase 6.0
UNKNOWN qPCR POSITIVE INDIRECT TarBase 6.0
Yun Chen et al. 2010 RP Umbilical Vein HUVEC HUVEC N/A
Location Method Result Regulation Validation Type Source
chr2:144388016-144388057 Luciferase Reporter Assay POSITIVE DIRECT TarBase 6.0
CDKN1C hsa-miR-221-3p low: 2 high: 0 1 2 1 -
Low-throughput experiments (2 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Kim Young-Kook et al. 2009 RP Gastric SNU638 SNU638 N/A
Location Method Result Regulation Validation Type Source
chr11:2883815-2883848 Luciferase Reporter Assay POSITIVE DIRECT TarBase 8.0
Kim Young-Kook et al. 2009 RP Gastric N/A HELA N/A
Location Method Result Regulation Validation Type Source
chr11:2883815-2883848 Luciferase Reporter Assay POSITIVE DIRECT TarBase 8.0
TBK1 hsa-miR-221-3p low: 2 high: 1 1 1 2 -
Low-throughput experiments (2 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Pascal Pineau et al. 2010 WB N/A N/A N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Western Blot POSITIVE INDIRECT TarBase 6.0
Pascal Pineau et al. 2010 RP Breast Cancerous Tissues N/A HEK293T N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Luciferase Reporter Assay POSITIVE DIRECT TarBase 6.0
High-throughput experiments (1 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Pascal Pineau et al. 2010 MA N/A N/A N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Microarrays POSITIVE INDIRECT TarBase 6.0
DICER1 hsa-miR-221-3p low: 2 high: 0 1 2 2 0.551
Low-throughput experiments (2 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Dawn R Cochrane et al. 2010 WB Mammary Gland T47D N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Western Blot POSITIVE INDIRECT TarBase 7.0
Dawn R Cochrane et al. 2010 RP Uterus/Endometrium HEC50 HEC50 N/A
Location Method Result Regulation Validation Type Source
chr14:95087607-95087621 Luciferase Reporter Assay POSITIVE DIRECT TarBase 7.0
ETS2 hsa-miR-221-3p low: 2 high: 0 1 1 1 0.607
Low-throughput experiments (2 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Yu-Hsuan Wu et al. 2011 qP Skin HMEC1 N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN qPCR POSITIVE INDIRECT TarBase 7.0
Yu-Hsuan Wu et al. 2011 RP Skin HMEC1 HEK293T N/A
Location Method Result Regulation Validation Type Source
chr21:38823999-38824023 Luciferase Reporter Assay POSITIVE DIRECT TarBase 7.0
DVL2 hsa-miR-221-3p low: 2 high: 0 1 1 1 -
Low-throughput experiments (2 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Zheng C et al. 2011 WB qP N/A N/A N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Western Blot POSITIVE INDIRECT TarBase 6.0
UNKNOWN qPCR POSITIVE INDIRECT TarBase 6.0
ESR1 hsa-miR-221-3p low: 2 high: 0 1 1 1 -
Low-throughput experiments (1 positive, 1 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Dawn R Cochrane et al. 2010 RP RP Mammary Gland MCF7 MCF7 N/A
Location Method Result Regulation Validation Type Source
chr6:152101091-152101437 Luciferase Reporter Assay POSITIVE DIRECT TarBase 7.0
chr6:152102551-152103214 Luciferase Reporter Assay NEGATIVE DIRECT TarBase 7.0
GAX(hsa) hsa-miR-221-3p low: 2 high: 0 1 1 1 -
Low-throughput experiments (2 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Yun Chen et al. 2010 WB qP N/A N/A N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Western Blot POSITIVE INDIRECT TarBase 6.0
UNKNOWN qPCR POSITIVE INDIRECT TarBase 6.0
FOS hsa-miR-221-3p low: 1 high: 2 3 3 3 0.852
Low-throughput experiments (1 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Atsuhiko Ichimura et al. 2010 RP Kidney HEK293 HEK293 N/A
Location Method Result Regulation Validation Type Source
chr14:75281496-75281842 Luciferase Reporter Assay POSITIVE DIRECT TarBase 8.0
High-throughput experiments (2 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Kameswaran V et al. 2014 IP Pancreas BETA Cells N/A N/A
Location Method Result Regulation Validation Type Source
chr14:75281612-75281633 HITS-CLIP POSITIVE DIRECT TarBase 7.0
Balakrishnan I et al. 2014 IP Bone Marrow HMSC N/A N/A
Location Method Result Regulation Validation Type Source
chr14:75281612-75281633 HITS-CLIP POSITIVE DIRECT TarBase 7.0