Please cite:
Dimitra Karagkouni, Maria D. Paraskevopoulou, Serafeim Chatzopoulos, Ioannis S. Vlachos, Spyros Tastsoglou, Ilias Kanellos, Dimitris Papadimitriou, Ioannis Kavakiotis, Sofia Maniou, Giorgos Skoufos, Thanasis Vergoulis, Theodore Dalamagas, Artemis G. Hatzigeorgiou; DIANA-TarBase v8: a decade-long collection of experimentally supported miRNA–gene interactions, Nucleic Acids Research, gkx1141, https://doi.org/10.1093/nar/gkx1141
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hsa-miR-221-5p


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Interactions: 968, Experiments: (low: , high: , unknown: ) Cell lines: , Tissues: , Publications:
Gene name miRNA name Experiments
throughput
Publications Cell lines Tissues Pred. Score
NUFIP2 hsa-miR-221-5p low: 0 high: 11 1 1 1 0.770
High-throughput experiments (11 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Karginov FV et al. 2013 IP Kidney 293S N/A treatment:hippuristanol
Location Method Result Regulation Validation Type Source
chr17:29263937-29263957 HITS-CLIP POSITIVE DIRECT TarBase 7.0
chr17:29263937-29263957 HITS-CLIP POSITIVE DIRECT TarBase 7.0
chr17:29263937-29263957 HITS-CLIP POSITIVE DIRECT TarBase 7.0
Karginov FV et al. 2013 IP Kidney 293S N/A treatment: emetine
Location Method Result Regulation Validation Type Source
chr17:29263937-29263957 HITS-CLIP POSITIVE DIRECT TarBase 7.0
chr17:29263937-29263957 HITS-CLIP POSITIVE DIRECT TarBase 7.0
Karginov FV et al. 2013 IP Kidney 293S N/A treatment: arsenite
Location Method Result Regulation Validation Type Source
chr17:29263937-29263957 HITS-CLIP POSITIVE DIRECT TarBase 7.0
Karginov FV et al. 2013 IP Kidney 293S N/A no treatment (control)
Location Method Result Regulation Validation Type Source
chr17:29263937-29263957 HITS-CLIP POSITIVE DIRECT TarBase 7.0
chr17:29263937-29263957 HITS-CLIP POSITIVE DIRECT TarBase 7.0
chr17:29263937-29263957 HITS-CLIP POSITIVE DIRECT TarBase 7.0
chr17:29263937-29263957 HITS-CLIP POSITIVE DIRECT TarBase 7.0
chr17:29263937-29263957 HITS-CLIP POSITIVE DIRECT TarBase 7.0
AHNAK hsa-miR-221-5p low: 0 high: 6 2 4 3 0.552
High-throughput experiments (6 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Kameswaran V et al. 2014 IP Pancreas BETA Cells N/A N/A
Location Method Result Regulation Validation Type Source
chr11:62522202-62522210 HITS-CLIP POSITIVE DIRECT TarBase 7.0
Balakrishnan I et al. 2014 IP Umbilical Vein HUVEC N/A N/A
Location Method Result Regulation Validation Type Source
chr11:62532135-62532145 HITS-CLIP POSITIVE DIRECT TarBase 7.0
chr11:62518371-62518396 HITS-CLIP POSITIVE DIRECT TarBase 7.0
Balakrishnan I et al. 2014 IP Bone Marrow HS27A N/A N/A
Location Method Result Regulation Validation Type Source
chr11:62532135-62532145 HITS-CLIP POSITIVE DIRECT TarBase 7.0
chr11:62518371-62518396 HITS-CLIP POSITIVE DIRECT TarBase 7.0
Balakrishnan I et al. 2014 IP Bone Marrow HMSC N/A N/A
Location Method Result Regulation Validation Type Source
chr11:62529064-62529084 HITS-CLIP POSITIVE DIRECT TarBase 7.0
FLNB hsa-miR-221-5p low: 0 high: 6 2 4 3 -
High-throughput experiments (6 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Kameswaran V et al. 2014 IP Pancreas BETA Cells N/A N/A
Location Method Result Regulation Validation Type Source
chr3:58159668-58159688 HITS-CLIP POSITIVE DIRECT TarBase 7.0
Balakrishnan I et al. 2014 IP Umbilical Vein HUVEC N/A N/A
Location Method Result Regulation Validation Type Source
chr3:58168516-58168538 HITS-CLIP POSITIVE DIRECT TarBase 7.0
chr3:58153626-58153643 HITS-CLIP POSITIVE DIRECT TarBase 7.0
chr3:58109605-58109629 HITS-CLIP POSITIVE DIRECT TarBase 7.0
Balakrishnan I et al. 2014 IP Bone Marrow HS5 N/A N/A
Location Method Result Regulation Validation Type Source
chr3:58146905-58146922 HITS-CLIP POSITIVE DIRECT TarBase 7.0
Balakrishnan I et al. 2014 IP Bone Marrow HMSC N/A N/A
Location Method Result Regulation Validation Type Source
chr3:58146905-58146922 HITS-CLIP POSITIVE DIRECT TarBase 7.0
ARHGDIA hsa-miR-221-5p low: 0 high: 5 2 2 2 0.701
High-throughput experiments (5 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Karginov FV et al. 2013 IP Kidney 293S N/A treatment:hippuristanol
Location Method Result Regulation Validation Type Source
chr17:81868613-81868619 HITS-CLIP POSITIVE DIRECT TarBase 7.0
Karginov FV et al. 2013 IP Kidney 293S N/A treatment: emetine
Location Method Result Regulation Validation Type Source
chr17:81868613-81868619 HITS-CLIP POSITIVE DIRECT TarBase 7.0
Karginov FV et al. 2013 IP Kidney 293S N/A no treatment (control)
Location Method Result Regulation Validation Type Source
chr17:81867782-81867806 HITS-CLIP POSITIVE DIRECT TarBase 7.0
chr17:81867782-81867806 HITS-CLIP POSITIVE DIRECT TarBase 7.0
Balakrishnan I et al. 2014 IP Umbilical Vein HUVEC N/A N/A
Location Method Result Regulation Validation Type Source
chr17:81867782-81867806 HITS-CLIP POSITIVE DIRECT TarBase 7.0
BAG3 hsa-miR-221-5p low: 0 high: 5 2 4 3 0.460
High-throughput experiments (5 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Pillai MM et al. 2014 IP Mammary Gland MDAMB231 N/A N/A
Location Method Result Regulation Validation Type Source
chr10:119676974-119676994 HITS-CLIP POSITIVE DIRECT TarBase 7.0
Balakrishnan I et al. 2014 IP Umbilical Vein HUVEC N/A N/A
Location Method Result Regulation Validation Type Source
chr10:119677046-119677074 HITS-CLIP POSITIVE DIRECT TarBase 7.0
chr10:119676974-119676994 HITS-CLIP POSITIVE DIRECT TarBase 7.0
Balakrishnan I et al. 2014 IP Bone Marrow HS5 N/A N/A
Location Method Result Regulation Validation Type Source
chr10:119676974-119676994 HITS-CLIP POSITIVE DIRECT TarBase 7.0
Balakrishnan I et al. 2014 IP Bone Marrow HS27A N/A N/A
Location Method Result Regulation Validation Type Source
chr10:119676974-119676994 HITS-CLIP POSITIVE DIRECT TarBase 7.0
BRPF3 hsa-miR-221-5p low: 0 high: 5 2 2 2 -
High-throughput experiments (5 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Karginov FV et al. 2013 IP Kidney 293S N/A treatment: arsenite
Location Method Result Regulation Validation Type Source
chr6:36231240-36231266 HITS-CLIP POSITIVE DIRECT TarBase 7.0
chr6:36231233-36231251 HITS-CLIP POSITIVE DIRECT TarBase 7.0
Karginov FV et al. 2013 IP Kidney 293S N/A no treatment (control)
Location Method Result Regulation Validation Type Source
chr6:36231240-36231266 HITS-CLIP POSITIVE DIRECT TarBase 7.0
chr6:36231233-36231251 HITS-CLIP POSITIVE DIRECT TarBase 7.0
Kameswaran V et al. 2014 IP Pancreas BETA Cells N/A N/A
Location Method Result Regulation Validation Type Source
chr6:36232338-36232344 HITS-CLIP POSITIVE DIRECT TarBase 7.0
MKNK2 hsa-miR-221-5p low: 0 high: 5 1 1 1 -
High-throughput experiments (5 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Karginov FV et al. 2013 IP Kidney 293S N/A treatment:hippuristanol
Location Method Result Regulation Validation Type Source
chr19:2037569-2037587 HITS-CLIP POSITIVE DIRECT TarBase 7.0
chr19:2037569-2037587 HITS-CLIP POSITIVE DIRECT TarBase 7.0
chr19:2037569-2037587 HITS-CLIP POSITIVE DIRECT TarBase 7.0
Karginov FV et al. 2013 IP Kidney 293S N/A no treatment (control)
Location Method Result Regulation Validation Type Source
chr19:2037569-2037587 HITS-CLIP POSITIVE DIRECT TarBase 7.0
chr19:2037569-2037587 HITS-CLIP POSITIVE DIRECT TarBase 7.0
GCN1L1 hsa-miR-221-5p low: 0 high: 4 4 4 4 -
High-throughput experiments (4 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Pillai MM et al. 2014 IP Mammary Gland MDAMB231 N/A N/A
Location Method Result Regulation Validation Type Source
chr12:120158544-120158567 HITS-CLIP POSITIVE DIRECT TarBase 7.0
Karginov FV et al. 2013 IP Kidney 293S N/A no treatment (control)
Location Method Result Regulation Validation Type Source
chr12:120162931-120162946 HITS-CLIP POSITIVE DIRECT TarBase 7.0
Kameswaran V et al. 2014 IP Pancreas BETA Cells N/A N/A
Location Method Result Regulation Validation Type Source
chr12:120162931-120162946 HITS-CLIP POSITIVE DIRECT TarBase 7.0
Balakrishnan I et al. 2014 IP Umbilical Vein HUVEC N/A N/A
Location Method Result Regulation Validation Type Source
chr12:120127890-120127896 HITS-CLIP POSITIVE DIRECT TarBase 7.0
PRRC2B hsa-miR-221-5p low: 0 high: 4 2 2 2 -
High-throughput experiments (4 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Karginov FV et al. 2013 IP Kidney 293S N/A treatment: emetine
Location Method Result Regulation Validation Type Source
chr9:131498626-131498652 HITS-CLIP POSITIVE DIRECT TarBase 7.0
Karginov FV et al. 2013 IP Kidney 293S N/A treatment: arsenite
Location Method Result Regulation Validation Type Source
chr9:131498899-131498925 HITS-CLIP POSITIVE DIRECT TarBase 7.0
chr9:131498332-131498348 HITS-CLIP POSITIVE DIRECT TarBase 7.0
Balakrishnan I et al. 2014 IP Umbilical Vein HUVEC N/A N/A
Location Method Result Regulation Validation Type Source
chr9:131482369-131482392 HITS-CLIP POSITIVE DIRECT TarBase 7.0
KIF23 hsa-miR-221-5p low: 0 high: 4 2 3 3 -
High-throughput experiments (4 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Pillai MM et al. 2014 IP Mammary Gland MDAMB231 N/A N/A
Location Method Result Regulation Validation Type Source
chr15:69440946-69440961 HITS-CLIP POSITIVE DIRECT TarBase 7.0
Balakrishnan I et al. 2014 IP Umbilical Vein HUVEC N/A N/A
Location Method Result Regulation Validation Type Source
chr15:69440023-69440030 HITS-CLIP POSITIVE DIRECT TarBase 7.0
Balakrishnan I et al. 2014 IP Bone Marrow HS5 N/A N/A
Location Method Result Regulation Validation Type Source
chr15:69440946-69440961 HITS-CLIP POSITIVE DIRECT TarBase 7.0
chr15:69440023-69440030 HITS-CLIP POSITIVE DIRECT TarBase 7.0
SON hsa-miR-221-5p low: 0 high: 4 2 2 2 -
High-throughput experiments (4 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Karginov FV et al. 2013 IP Kidney 293S N/A no treatment (control)
Location Method Result Regulation Validation Type Source
chr21:33551109-33551132 HITS-CLIP POSITIVE DIRECT TarBase 7.0
chr21:33550491-33550517 HITS-CLIP POSITIVE DIRECT TarBase 7.0
Karginov FV et al. 2013 IP Kidney 293S N/A treatment:hippuristanol
Location Method Result Regulation Validation Type Source
chr21:33550459-33550484 HITS-CLIP POSITIVE DIRECT TarBase 7.0
Balakrishnan I et al. 2014 IP Umbilical Vein HUVEC N/A N/A
Location Method Result Regulation Validation Type Source
chr21:33546280-33546297 HITS-CLIP POSITIVE DIRECT TarBase 7.0
PCBP1 hsa-miR-221-5p low: 0 high: 4 2 3 3 0.683
High-throughput experiments (4 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Skalsky Rebecca L. et al. 2012 IP N/A EF3DAGO2 N/A N/A
Location Method Result Regulation Validation Type Source
chr2:70088762-70088781 PAR-CLIP POSITIVE DIRECT TarBase 7.0
Balakrishnan I et al. 2014 IP Umbilical Vein HUVEC N/A N/A
Location Method Result Regulation Validation Type Source
chr2:70088875-70088896 HITS-CLIP POSITIVE DIRECT TarBase 7.0
chr2:70088762-70088781 HITS-CLIP POSITIVE DIRECT TarBase 7.0
Balakrishnan I et al. 2014 IP Bone Marrow HS5 N/A N/A
Location Method Result Regulation Validation Type Source
chr2:70088442-70088465 HITS-CLIP POSITIVE DIRECT TarBase 7.0
B4GALNT4 hsa-miR-221-5p low: 0 high: 4 1 1 1 -
High-throughput experiments (4 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Karginov FV et al. 2013 IP Kidney 293S N/A treatment:emetine
Location Method Result Regulation Validation Type Source
chr11:379685-379703 HITS-CLIP POSITIVE DIRECT TarBase 7.0
Karginov FV et al. 2013 IP Kidney 293S N/A treatment: arsenite
Location Method Result Regulation Validation Type Source
chr11:376227-376252 HITS-CLIP POSITIVE DIRECT TarBase 7.0
Karginov FV et al. 2013 IP Kidney 293S N/A no treatment (control)
Location Method Result Regulation Validation Type Source
chr11:379652-379674 HITS-CLIP POSITIVE DIRECT TarBase 7.0
chr11:376227-376252 HITS-CLIP POSITIVE DIRECT TarBase 7.0
MBD3 hsa-miR-221-5p low: 0 high: 4 2 2 2 -
High-throughput experiments (4 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Karginov FV et al. 2013 IP Kidney 293S N/A no treatment (control)
Location Method Result Regulation Validation Type Source
chr19:1577357-1577379 HITS-CLIP POSITIVE DIRECT TarBase 7.0
Balakrishnan I et al. 2014 IP Umbilical Vein HUVEC N/A N/A
Location Method Result Regulation Validation Type Source
chr19:1577357-1577379 HITS-CLIP POSITIVE DIRECT TarBase 7.0
chr19:1577054-1577071 HITS-CLIP POSITIVE DIRECT TarBase 7.0
chr19:1576842-1576869 HITS-CLIP POSITIVE DIRECT TarBase 7.0
DYNC1H1 hsa-miR-221-5p low: 0 high: 4 2 2 2 -
High-throughput experiments (4 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Karginov FV et al. 2013 IP Kidney 293S N/A treatment:emetine
Location Method Result Regulation Validation Type Source
chr14:102004931-102004952 HITS-CLIP POSITIVE DIRECT TarBase 7.0
Balakrishnan I et al. 2014 IP Umbilical Vein HUVEC N/A N/A
Location Method Result Regulation Validation Type Source
chr14:102048570-102048585 HITS-CLIP POSITIVE DIRECT TarBase 7.0
chr14:102028029-102028055 HITS-CLIP POSITIVE DIRECT TarBase 7.0
chr14:102027715-102027743 HITS-CLIP POSITIVE DIRECT TarBase 7.0
NISCH hsa-miR-221-5p low: 0 high: 3 1 1 1 0.603
High-throughput experiments (3 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Karginov FV et al. 2013 IP Kidney 293S N/A treatment:hippuristanol
Location Method Result Regulation Validation Type Source
chr3:52480466-52480482 HITS-CLIP POSITIVE DIRECT TarBase 7.0
Karginov FV et al. 2013 IP Kidney 293S N/A treatment: arsenite
Location Method Result Regulation Validation Type Source
chr3:52480466-52480482 HITS-CLIP POSITIVE DIRECT TarBase 7.0
Karginov FV et al. 2013 IP Kidney 293S N/A no treatment (control)
Location Method Result Regulation Validation Type Source
chr3:52480466-52480482 HITS-CLIP POSITIVE DIRECT TarBase 7.0
PFN2 hsa-miR-221-5p low: 0 high: 3 2 3 3 -
High-throughput experiments (3 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Kameswaran V et al. 2014 IP Pancreas BETA Cells N/A N/A
Location Method Result Regulation Validation Type Source
chr3:149965920-149965947 HITS-CLIP POSITIVE DIRECT TarBase 7.0
Balakrishnan I et al. 2014 IP Umbilical Vein HUVEC N/A N/A
Location Method Result Regulation Validation Type Source
chr3:149970802-149970825 HITS-CLIP POSITIVE DIRECT TarBase 7.0
Balakrishnan I et al. 2014 IP Bone Marrow HMSC N/A N/A
Location Method Result Regulation Validation Type Source
chr3:149970802-149970825 HITS-CLIP POSITIVE DIRECT TarBase 7.0
SCD hsa-miR-221-5p low: 0 high: 3 2 3 3 0.571
High-throughput experiments (3 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Kameswaran V et al. 2014 IP Pancreas BETA Cells N/A N/A
Location Method Result Regulation Validation Type Source
chr10:100362210-100362233 HITS-CLIP POSITIVE DIRECT TarBase 7.0
Balakrishnan I et al. 2014 IP Umbilical Vein HUVEC N/A N/A
Location Method Result Regulation Validation Type Source
chr10:100362210-100362233 HITS-CLIP POSITIVE DIRECT TarBase 7.0
Balakrishnan I et al. 2014 IP Bone Marrow HS27A N/A N/A
Location Method Result Regulation Validation Type Source
chr10:100364265-100364286 HITS-CLIP POSITIVE DIRECT TarBase 7.0
TNRC6B hsa-miR-221-5p low: 0 high: 3 3 3 3 -
High-throughput experiments (3 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Pillai MM et al. 2014 IP Mammary Gland MDAMB231 N/A N/A
Location Method Result Regulation Validation Type Source
chr22:40333403-40333423 HITS-CLIP POSITIVE DIRECT TarBase 7.0
Karginov FV et al. 2013 IP Kidney 293S N/A no treatment (control)
Location Method Result Regulation Validation Type Source
chr22:40324599-40324620 HITS-CLIP POSITIVE DIRECT TarBase 7.0
Balakrishnan I et al. 2014 IP Umbilical Vein HUVEC N/A N/A
Location Method Result Regulation Validation Type Source
chr22:40324599-40324620 HITS-CLIP POSITIVE DIRECT TarBase 7.0
ACIN1 hsa-miR-221-5p low: 0 high: 3 2 2 2 -
High-throughput experiments (3 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Pillai MM et al. 2014 IP Mammary Gland MDAMB231 N/A N/A
Location Method Result Regulation Validation Type Source
chr14:23063486-23063501 HITS-CLIP POSITIVE DIRECT TarBase 7.0
Karginov FV et al. 2013 IP Kidney 293S N/A treatment: arsenite
Location Method Result Regulation Validation Type Source
chr14:23058776-23058799 HITS-CLIP POSITIVE DIRECT TarBase 7.0
Karginov FV et al. 2013 IP Kidney 293S N/A no treatment (control)
Location Method Result Regulation Validation Type Source
chr14:23058776-23058799 HITS-CLIP POSITIVE DIRECT TarBase 7.0