Please cite:
Dimitra Karagkouni, Maria D. Paraskevopoulou, Serafeim Chatzopoulos, Ioannis S. Vlachos, Spyros Tastsoglou, Ilias Kanellos, Dimitris Papadimitriou, Ioannis Kavakiotis, Sofia Maniou, Giorgos Skoufos, Thanasis Vergoulis, Theodore Dalamagas, Artemis G. Hatzigeorgiou; DIANA-TarBase v8: a decade-long collection of experimentally supported miRNA–gene interactions, Nucleic Acids Research, gkx1141, https://doi.org/10.1093/nar/gkx1141
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hsa-miR-449a


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Filters
Interactions: 898, Experiments: (low: , high: , unknown: ) Cell lines: , Tissues: , Publications:
Gene name miRNA name Experiments
throughput
Publications Cell lines Tissues Pred. Score
HNF4A hsa-miR-449a low: 4 high: 0 2 1 1 -
Low-throughput experiments (4 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Zhongyan Wang et al. 2013 RP Liver HEPG2 HEPG2 N/A
Location Method Result Regulation Validation Type Source
chr20:44429814-44429836 Luciferase Reporter Assay POSITIVE DIRECT TarBase 8.0
chr20:44429904-44429926 Luciferase Reporter Assay POSITIVE DIRECT TarBase 8.0
Anuradha Ramamoorthy et al. 2012 WB Liver HEPG2 N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Western Blot POSITIVE INDIRECT TarBase 7.0
Anuradha Ramamoorthy et al. 2012 RP Liver HEPG2 HELA N/A
Location Method Result Regulation Validation Type Source
chr20:44429727-44431139 Luciferase Reporter Assay POSITIVE DIRECT TarBase 7.0
CDK6 hsa-miR-449a low: 3 high: 0 4 1 2 0.830
Low-throughput experiments (3 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Xiaojing Yang et al. 2009 WB N/A N/A N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Western Blot POSITIVE INDIRECT TarBase 6.0
Xiaojing Yang et al. 2009 RP Breast Cancerous Tissues N/A HCT116 N/A
Location Method Result Regulation Validation Type Source
chr7:92614045-92614067 Luciferase Reporter Assay POSITIVE DIRECT TarBase 6.0
chr7:92605952-92605974 Luciferase Reporter Assay POSITIVE DIRECT TarBase 6.0
Other Databases
Publication Methods Tissue Cell line Tested cell line Exp. condition
Zhang Er-bao et al. 2014 O N/A N/A N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Other UNKNOWN UNKNOWN miRTarBase
Whisnant Adam W et al. 2013 O N/A N/A N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Other UNKNOWN UNKNOWN miRTarBase
LI LI-PING et al. 2014 O N/A N/A N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Other UNKNOWN UNKNOWN miRTarBase
Xiaojing Yang et al. 2009 O N/A N/A N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Other UNKNOWN UNKNOWN miRTarBase
MET hsa-miR-449a low: 3 high: 0 2 2 2 -
Low-throughput experiments (3 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Bou Kheir Tony et al. 2011 WB qP Gastric SNU638 HEK293 N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Western Blot POSITIVE INDIRECT TarBase 7.0
UNKNOWN qPCR POSITIVE INDIRECT TarBase 7.0
Bou Kheir Tony et al. 2011 RP Gastric SNU638 HEK293 Dual Luciferase Reporter Assay
Location Method Result Regulation Validation Type Source
chr7:116798262-116798309 Luciferase Reporter Assay POSITIVE DIRECT TarBase 7.0
Other Databases
Publication Methods Tissue Cell line Tested cell line Exp. condition
et al. O N/A N/A N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Other UNKNOWN UNKNOWN miRTarBase
Bou Kheir Tony et al. 2011 O N/A N/A N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Other UNKNOWN UNKNOWN miRTarBase
SIRT1 hsa-miR-449a low: 3 high: 0 1 2 2 -
Low-throughput experiments (3 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Bou Kheir Tony et al. 2011 WB qP Gastric SNU638 HEK293 N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Western Blot POSITIVE INDIRECT TarBase 7.0
UNKNOWN qPCR POSITIVE INDIRECT TarBase 7.0
Bou Kheir Tony et al. 2011 RP Gastric SNU638 HEK293 Dual Luciferase Reporter Assay
Location Method Result Regulation Validation Type Source
chr10:67918009-67918048 Luciferase Reporter Assay POSITIVE DIRECT TarBase 7.0
Other Databases
Publication Methods Tissue Cell line Tested cell line Exp. condition
Bou Kheir Tony et al. 2011 O N/A N/A N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Other UNKNOWN UNKNOWN miRTarBase
GMNN hsa-miR-449a low: 3 high: 0 1 1 1 -
Low-throughput experiments (3 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Bou Kheir Tony et al. 2011 WB qP Gastric SNU638 HEK293 N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Western Blot POSITIVE INDIRECT TarBase 7.0
UNKNOWN qPCR POSITIVE INDIRECT TarBase 7.0
Bou Kheir Tony et al. 2011 RP Gastric SNU638 HEK293 Dual Luciferase Reporter Assay
Location Method Result Regulation Validation Type Source
chr6:24785812-24785855 Luciferase Reporter Assay POSITIVE DIRECT TarBase 7.0
HDAC1 hsa-miR-449a low: 3 high: 0 1 1 1 -
Low-throughput experiments (3 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Bou Kheir Tony et al. 2011 WB qP Gastric SNU638 HEK293 N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Western Blot POSITIVE INDIRECT TarBase 7.0
UNKNOWN qPCR POSITIVE INDIRECT TarBase 7.0
Bou Kheir Tony et al. 2011 RP Gastric SNU638 HEK293 Dual Luciferase Reporter Assay
Location Method Result Regulation Validation Type Source
chr1:32333484-32333516 Luciferase Reporter Assay POSITIVE DIRECT TarBase 7.0
CCNE2 hsa-miR-449a low: 3 high: 0 1 1 1 -
Low-throughput experiments (3 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Bou Kheir Tony et al. 2011 WB qP Gastric SNU638 HEK293 N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Western Blot POSITIVE INDIRECT TarBase 7.0
UNKNOWN qPCR POSITIVE INDIRECT TarBase 7.0
Bou Kheir Tony et al. 2011 RP Gastric SNU638 HEK293 Dual Luciferase Reporter Assay
Location Method Result Regulation Validation Type Source
chr8:94881485-94881527 Luciferase Reporter Assay POSITIVE DIRECT TarBase 7.0
WISP2 hsa-miR-449a low: 2 high: 0 1 1 1 0.494
Low-throughput experiments (2 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Dimitrios Iliopoulos et al. 2009 qP Adrenal Gland PPNAD N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN qPCR POSITIVE INDIRECT TarBase 7.0
Dimitrios Iliopoulos et al. 2009 RP Adrenal Gland PPNAD HEK293 N/A
Location Method Result Regulation Validation Type Source
chr20:44727514-44727536 Luciferase Reporter Assay POSITIVE DIRECT TarBase 7.0
CDC25A hsa-miR-449a low: 2 high: 0 1 1 2 -
Low-throughput experiments (2 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Xiaojing Yang et al. 2009 WB N/A N/A N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Western Blot POSITIVE INDIRECT TarBase 6.0
Xiaojing Yang et al. 2009 RP Breast Cancerous Tissues N/A HCT116 N/A
Location Method Result Regulation Validation Type Source
chr3:48158422-48158444 Luciferase Reporter Assay POSITIVE DIRECT TarBase 6.0
E2F3 hsa-miR-449a low: 1 high: 3 3 3 3 1.000
Low-throughput experiments (1 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Li X. et al. 2015 RP Gastric SGC7901 SGC7901 N/A
Location Method Result Regulation Validation Type Source
chr6:20493145-20493167 Luciferase Reporter Assay POSITIVE DIRECT TarBase 8.0
High-throughput experiments (3 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Xue Y et al. 2013 IP Cervix HELA N/A Hela cells were treated with control shRNA.
Location Method Result Regulation Validation Type Source
chr6:20493141-20493167 HITS-CLIP POSITIVE DIRECT TarBase 7.0
Karginov FV et al. 2013 IP Kidney 293S N/A treatment: arsenite
Location Method Result Regulation Validation Type Source
chr6:20493141-20493167 HITS-CLIP POSITIVE DIRECT TarBase 7.0
Karginov FV et al. 2013 IP Kidney 293S N/A no treatment (control)
Location Method Result Regulation Validation Type Source
chr6:20493141-20493167 HITS-CLIP POSITIVE DIRECT TarBase 7.0
PDGFRA hsa-miR-449a low: 1 high: 1 2 2 2 0.978
Low-throughput experiments (0 positive, 1 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Peng Yang et al. 2014 WB Stomach AGS N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Western Blot NEGATIVE INDIRECT TarBase 7.0
High-throughput experiments (1 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Balakrishnan I et al. 2014 IP Bone Marrow HS5 N/A N/A
Location Method Result Regulation Validation Type Source
chr4:54297927-54297948 HITS-CLIP POSITIVE DIRECT TarBase 7.0
PDGFRB hsa-miR-449a low: 1 high: 0 1 1 1 -
Low-throughput experiments (0 positive, 1 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Peng Yang et al. 2014 WB Stomach AGS N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Western Blot NEGATIVE INDIRECT TarBase 7.0
CDK4 hsa-miR-449a low: 1 high: 0 1 1 1 -
Low-throughput experiments (1 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Xiaojing Yang et al. 2009 WB N/A N/A N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Western Blot POSITIVE INDIRECT TarBase 6.0
ERBB2 hsa-miR-449a low: 1 high: 0 1 1 1 -
Low-throughput experiments (1 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Leivonen SK. et al. 2014 RP Breast JIMT1 JIMT1 N/A
Location Method Result Regulation Validation Type Source
chr17:39727713-39728672 Luciferase Reporter Assay POSITIVE DIRECT TarBase 8.0
TMEM132E hsa-miR-449a low: 0 high: 8 1 1 1 -
High-throughput experiments (8 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Karginov FV et al. 2013 IP Kidney 293S N/A treatment:hippuristanol
Location Method Result Regulation Validation Type Source
chr17:34638051-34638073 HITS-CLIP POSITIVE DIRECT TarBase 7.0
chr17:34638051-34638073 HITS-CLIP POSITIVE DIRECT TarBase 7.0
chr17:34638051-34638073 HITS-CLIP POSITIVE DIRECT TarBase 7.0
Karginov FV et al. 2013 IP Kidney 293S N/A treatment: arsenite
Location Method Result Regulation Validation Type Source
chr17:34638051-34638073 HITS-CLIP POSITIVE DIRECT TarBase 7.0
Karginov FV et al. 2013 IP Kidney 293S N/A no treatment (control)
Location Method Result Regulation Validation Type Source
chr17:34638051-34638073 HITS-CLIP POSITIVE DIRECT TarBase 7.0
chr17:34638051-34638073 HITS-CLIP POSITIVE DIRECT TarBase 7.0
chr17:34638051-34638073 HITS-CLIP POSITIVE DIRECT TarBase 7.0
chr17:34638051-34638073 HITS-CLIP POSITIVE DIRECT TarBase 7.0
IGFBP3 hsa-miR-449a low: 0 high: 7 3 3 3 -
High-throughput experiments (7 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Xue Y et al. 2013 IP Cervix HELA N/A Hela cells were treated with control shRNA.
Location Method Result Regulation Validation Type Source
chr7:45913789-45913817 HITS-CLIP POSITIVE DIRECT TarBase 7.0
Karginov FV et al. 2013 IP Kidney 293S N/A treatment:hippuristanol
Location Method Result Regulation Validation Type Source
chr7:45913789-45913817 HITS-CLIP POSITIVE DIRECT TarBase 7.0
chr7:45913789-45913817 HITS-CLIP POSITIVE DIRECT TarBase 7.0
Karginov FV et al. 2013 IP Kidney 293S N/A treatment: arsenite
Location Method Result Regulation Validation Type Source
chr7:45913789-45913817 HITS-CLIP POSITIVE DIRECT TarBase 7.0
Karginov FV et al. 2013 IP Kidney 293S N/A no treatment (control)
Location Method Result Regulation Validation Type Source
chr7:45913789-45913817 HITS-CLIP POSITIVE DIRECT TarBase 7.0
chr7:45913789-45913817 HITS-CLIP POSITIVE DIRECT TarBase 7.0
Kameswaran V et al. 2014 IP Pancreas BETA Cells N/A N/A
Location Method Result Regulation Validation Type Source
chr7:45913789-45913817 HITS-CLIP POSITIVE DIRECT TarBase 7.0
TSPAN3 hsa-miR-449a low: 0 high: 6 2 2 2 -
High-throughput experiments (6 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Karginov FV et al. 2013 IP Kidney 293S N/A treatment:hippuristanol
Location Method Result Regulation Validation Type Source
chr15:77052824-77052848 HITS-CLIP POSITIVE DIRECT TarBase 7.0
Karginov FV et al. 2013 IP Kidney 293S N/A treatment: arsenite
Location Method Result Regulation Validation Type Source
chr15:77052824-77052848 HITS-CLIP POSITIVE DIRECT TarBase 7.0
Karginov FV et al. 2013 IP Kidney 293S N/A no treatment (control)
Location Method Result Regulation Validation Type Source
chr15:77052824-77052848 HITS-CLIP POSITIVE DIRECT TarBase 7.0
chr15:77052824-77052848 HITS-CLIP POSITIVE DIRECT TarBase 7.0
chr15:77052824-77052848 HITS-CLIP POSITIVE DIRECT TarBase 7.0
Haecker Irina et al. 2012 IP Bone Marrow BCBL1 N/A N/A
Location Method Result Regulation Validation Type Source
chr15:77052824-77052848 HITS-CLIP POSITIVE DIRECT TarBase 7.0
CHD1 hsa-miR-449a low: 0 high: 5 4 4 3 -
High-throughput experiments (5 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Skalsky Rebecca L. et al. 2012 IP N/A LCLBACD3 N/A N/A
Location Method Result Regulation Validation Type Source
chr5:98856098-98856118 PAR-CLIP POSITIVE DIRECT TarBase 7.0
Karginov FV et al. 2013 IP Kidney 293S N/A treatment: arsenite
Location Method Result Regulation Validation Type Source
chr5:98856098-98856118 HITS-CLIP POSITIVE DIRECT TarBase 7.0
chr5:98855899-98855925 HITS-CLIP POSITIVE DIRECT TarBase 7.0
Haecker Irina et al. 2012 IP Bone Marrow BCBL1 N/A N/A
Location Method Result Regulation Validation Type Source
chr5:98856098-98856118 HITS-CLIP POSITIVE DIRECT TarBase 7.0
Balakrishnan I et al. 2014 IP Bone Marrow HS5 N/A N/A
Location Method Result Regulation Validation Type Source
chr5:98856098-98856118 HITS-CLIP POSITIVE DIRECT TarBase 7.0
ZNF621 hsa-miR-449a low: 0 high: 5 1 1 1 -
High-throughput experiments (5 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Karginov FV et al. 2013 IP Kidney 293S N/A treatment:hippuristanol
Location Method Result Regulation Validation Type Source
chr3:40535256-40535277 HITS-CLIP POSITIVE DIRECT TarBase 7.0
chr3:40535256-40535277 HITS-CLIP POSITIVE DIRECT TarBase 7.0
Karginov FV et al. 2013 IP Kidney 293S N/A no treatment (control)
Location Method Result Regulation Validation Type Source
chr3:40535256-40535277 HITS-CLIP POSITIVE DIRECT TarBase 7.0
chr3:40535256-40535277 HITS-CLIP POSITIVE DIRECT TarBase 7.0
chr3:40535256-40535277 HITS-CLIP POSITIVE DIRECT TarBase 7.0
MKNK2 hsa-miR-449a low: 0 high: 4 2 2 2 -
High-throughput experiments (4 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Karginov FV et al. 2013 IP Kidney 293S N/A treatment:hippuristanol
Location Method Result Regulation Validation Type Source
chr19:2039711-2039732 HITS-CLIP POSITIVE DIRECT TarBase 7.0
Karginov FV et al. 2013 IP Kidney 293S N/A treatment: arsenite
Location Method Result Regulation Validation Type Source
chr19:2039711-2039732 HITS-CLIP POSITIVE DIRECT TarBase 7.0
Karginov FV et al. 2013 IP Kidney 293S N/A no treatment (control)
Location Method Result Regulation Validation Type Source
chr19:2038073-2038096 HITS-CLIP POSITIVE DIRECT TarBase 7.0
Haecker Irina et al. 2012 IP Bone Marrow BCBL1 N/A N/A
Location Method Result Regulation Validation Type Source
chr19:2038073-2038096 HITS-CLIP POSITIVE DIRECT TarBase 7.0