Please cite:
Dimitra Karagkouni, Maria D. Paraskevopoulou, Serafeim Chatzopoulos, Ioannis S. Vlachos, Spyros Tastsoglou, Ilias Kanellos, Dimitris Papadimitriou, Ioannis Kavakiotis, Sofia Maniou, Giorgos Skoufos, Thanasis Vergoulis, Theodore Dalamagas, Artemis G. Hatzigeorgiou; DIANA-TarBase v8: a decade-long collection of experimentally supported miRNA–gene interactions, Nucleic Acids Research, gkx1141, https://doi.org/10.1093/nar/gkx1141
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hsa-miR-21-5p


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Interactions: 1588, Experiments: (low: , high: , unknown: ) Cell lines: , Tissues: , Publications:
Gene name miRNA name Experiments
throughput
Publications Cell lines Tissues Pred. Score
PTEN hsa-miR-21-5p low: 20 high: 1 10 16 9 -
Low-throughput experiments (19 positive, 1 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Ling S. et al. 2013 RP Vascular VSMC HEK293 N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Luciferase Reporter Assay POSITIVE DIRECT TarBase 8.0
Yi Yang et al. 2009 RP Mammary Gland MCF7 MCF7 N/A
Location Method Result Regulation Validation Type Source
chr10:87966649-87967523 Luciferase Reporter Assay NEGATIVE DIRECT TarBase 8.0
Zhou L. et al. 2013 RP Liver HCC Cell Lines HCC Cell Lines N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Luciferase Reporter Assay POSITIVE DIRECT TarBase 8.0
Xuan Zhou et al. 2010 RP Brain U251 U251 N/A
Location Method Result Regulation Validation Type Source
chr10:87965420-87965666 Luciferase Reporter Assay POSITIVE DIRECT TarBase 6.0
Xuan Zhou et al. 2010 WB N/A N/A N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Western Blot POSITIVE INDIRECT TarBase 6.0
Xuan Zhou et al. 2010 RP Brain LN229 LN229 N/A
Location Method Result Regulation Validation Type Source
chr10:87965420-87965666 Luciferase Reporter Assay POSITIVE DIRECT TarBase 6.0
Xuan Zhou et al. 2010 RP Brain H4 H4 N/A
Location Method Result Regulation Validation Type Source
chr10:87965420-87965666 Luciferase Reporter Assay POSITIVE DIRECT TarBase 6.0
Xuan Zhou et al. 2010 RP Nervous A172 A172 N/A
Location Method Result Regulation Validation Type Source
chr10:87965420-87965666 Luciferase Reporter Assay POSITIVE DIRECT TarBase 6.0
Yingjie Yu et al. 2012 WB Intestine HCT116 N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Western Blot POSITIVE INDIRECT TarBase 7.0
Qin X et al. 2012 WB qP RP Uterus/Endometrium KLE N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Western Blot POSITIVE INDIRECT TarBase 7.0
UNKNOWN qPCR POSITIVE INDIRECT TarBase 7.0
chr10:87967059-87967080 Luciferase Reporter Assay POSITIVE DIRECT TarBase 7.0
Fanyin Meng et al. 2007 RP Liver SNU182 SNU182 N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Luciferase Reporter Assay POSITIVE DIRECT TarBase 6.0
Fanyin Meng et al. 2007 RP Liver SKHEP1 SKHEP1 N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Luciferase Reporter Assay POSITIVE DIRECT TarBase 6.0
Fanyin Meng et al. 2007 RP Liver PLC/PRF/5 PLC/PRF/5 N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Luciferase Reporter Assay POSITIVE DIRECT TarBase 6.0
Fanyin Meng et al. 2007 RP Liver HEPG2 HEPG2 N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Luciferase Reporter Assay POSITIVE DIRECT TarBase 6.0
Fanyin Meng et al. 2006 RP Liver MZCHA1 MZCHA1 N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Luciferase Reporter Assay POSITIVE DIRECT TarBase 6.0
Ling-Zhi Liu et al. 2011 WB N/A N/A N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Western Blot POSITIVE INDIRECT TarBase 6.0
Nirmalya Dey et al. 2012 WB RP Kidney Renal Glomerular Mesangial Cell N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Western Blot POSITIVE INDIRECT TarBase 7.0
UNKNOWN Luciferase Reporter Assay POSITIVE DIRECT TarBase 7.0
High-throughput experiments (1 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Xuan Zhou et al. 2010 MA N/A N/A N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Microarrays POSITIVE INDIRECT TarBase 6.0
PDCD4 hsa-miR-21-5p low: 13 high: 1 4 7 3 1.000
Low-throughput experiments (11 positive, 2 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Yingjie Yu et al. 2012 WB Intestine HCT116 N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Western Blot POSITIVE INDIRECT TarBase 7.0
Xiaochuang Luo et al. 2014 RP Peripheral Blood RPMI8266 RPMI8266 N/A
Location Method Result Regulation Validation Type Source
chr10:110898110-110899983 Luciferase Reporter Assay POSITIVE DIRECT TarBase 7.0
Xiaochuang Luo et al. 2014 WB qP Peripheral Blood RPMI8266 N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Western Blot POSITIVE INDIRECT TarBase 7.0
UNKNOWN qPCR POSITIVE INDIRECT TarBase 7.0
Li X. et al. 2014 WB qP Kidney HK2 N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Western Blot NEGATIVE INDIRECT TarBase 7.0
UNKNOWN qPCR NEGATIVE INDIRECT TarBase 7.0
Li X. et al. 2014 WB qP Kidney CAKI1 N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Western Blot POSITIVE INDIRECT TarBase 7.0
UNKNOWN qPCR POSITIVE INDIRECT TarBase 7.0
Li X. et al. 2014 WB qP Kidney A498 N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Western Blot POSITIVE INDIRECT TarBase 7.0
UNKNOWN qPCR POSITIVE INDIRECT TarBase 7.0
Li X. et al. 2014 WB qP Kidney 786O N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Western Blot POSITIVE INDIRECT TarBase 7.0
UNKNOWN qPCR POSITIVE INDIRECT TarBase 7.0
Li X. et al. 2014 RP Kidney 786O 786O N/A
Location Method Result Regulation Validation Type Source
chr10:110898320-110898337 Luciferase Reporter Assay POSITIVE DIRECT TarBase 7.0
High-throughput experiments (1 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Qian Xiong et al. 2012 PR Peripheral Blood U266 N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN SILAC POSITIVE INDIRECT TarBase 7.0
RECK hsa-miR-21-5p low: 12 high: 1 4 7 6 -
Low-throughput experiments (12 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Zhou L. et al. 2013 RP Liver HCC Cell Lines HCC Cell Lines N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Luciferase Reporter Assay POSITIVE DIRECT TarBase 8.0
Zhiyu Zhang et al. 2008 WB O N/A N/A N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Western Blot POSITIVE INDIRECT TarBase 6.0
UNKNOWN Other POSITIVE INDIRECT TarBase 6.0
Zhiyu Zhang et al. 2008 RP Kidney HEK293 HEK293 N/A
Location Method Result Regulation Validation Type Source
chr9:36124062-36124311 Luciferase Reporter Assay POSITIVE DIRECT TarBase 6.0
Na Wang et al. 2013 WB Esophagus EC9706 N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Western Blot POSITIVE INDIRECT TarBase 7.0
Na Wang et al. 2013 WB Esophagus EC1 N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Western Blot POSITIVE INDIRECT TarBase 7.0
Na Wang et al. 2013 RP Esophagus EC9706 EC9706 N/A
Location Method Result Regulation Validation Type Source
chr9:36123046-36124451 Luciferase Reporter Assay POSITIVE DIRECT TarBase 7.0
Na Wang et al. 2013 RP Esophagus EC1 EC1 N/A
Location Method Result Regulation Validation Type Source
chr9:36123046-36124451 Luciferase Reporter Assay POSITIVE DIRECT TarBase 7.0
Galina Gabriely et al. 2008 WB qP N/A N/A N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Western Blot POSITIVE INDIRECT TarBase 6.0
UNKNOWN qPCR POSITIVE INDIRECT TarBase 6.0
Galina Gabriely et al. 2008 RP Cervix HELA N/A N/A
Location Method Result Regulation Validation Type Source
chr9:36123174-36124334 Luciferase Reporter Assay POSITIVE DIRECT TarBase 6.0
Galina Gabriely et al. 2008 RP Nervous A172 N/A N/A
Location Method Result Regulation Validation Type Source
chr9:36123174-36124334 Luciferase Reporter Assay POSITIVE DIRECT TarBase 6.0
High-throughput experiments (1 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Galina Gabriely et al. 2008 MA N/A N/A N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Microarrays POSITIVE INDIRECT TarBase 6.0
DOCK4 hsa-miR-21-5p low: 10 high: 0 1 1 1 -
Low-throughput experiments (3 positive, 7 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Hara Kang et al. 2012 RP RP Kidney COS7 N/A N/A
Location Method Result Regulation Validation Type Source
chr7:111727139-111727160 Luciferase Reporter Assay POSITIVE DIRECT TarBase 7.0
chr7:111728191-111728213 Luciferase Reporter Assay POSITIVE DIRECT TarBase 7.0
chr7:111726159-111728251 Luciferase Reporter Assay POSITIVE DIRECT TarBase 7.0
chr7:111726942-111726963 Luciferase Reporter Assay NEGATIVE DIRECT TarBase 7.0
chr7:111728094-111728128 Luciferase Reporter Assay NEGATIVE DIRECT TarBase 7.0
chr7:111727550-111727571 Luciferase Reporter Assay NEGATIVE DIRECT TarBase 7.0
chr7:111727114-111727135 Luciferase Reporter Assay NEGATIVE DIRECT TarBase 7.0
chr7:111728072-111728093 Luciferase Reporter Assay NEGATIVE DIRECT TarBase 7.0
chr7:111727225-111727246 Luciferase Reporter Assay NEGATIVE DIRECT TarBase 7.0
chr7:111726151-111726173 Luciferase Reporter Assay NEGATIVE DIRECT TarBase 7.0
TIMP3 hsa-miR-21-5p low: 8 high: 1 2 5 4 -
Low-throughput experiments (8 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Na Wang et al. 2013 WB Esophagus EC9706 N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Western Blot POSITIVE INDIRECT TarBase 7.0
Na Wang et al. 2013 WB Esophagus EC1 N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Western Blot POSITIVE INDIRECT TarBase 7.0
Na Wang et al. 2013 RP Esophagus EC9706 EC9706 N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Luciferase Reporter Assay POSITIVE DIRECT TarBase 7.0
Na Wang et al. 2013 RP Esophagus EC1 EC1 N/A
Location Method Result Regulation Validation Type Source
chr22:32859378-32863043 Luciferase Reporter Assay POSITIVE DIRECT TarBase 7.0
Galina Gabriely et al. 2008 WB qP N/A N/A N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Western Blot POSITIVE INDIRECT TarBase 6.0
UNKNOWN qPCR POSITIVE INDIRECT TarBase 6.0
Galina Gabriely et al. 2008 RP Cervix HELA N/A N/A
Location Method Result Regulation Validation Type Source
chr22:32860044-32861935 Luciferase Reporter Assay POSITIVE DIRECT TarBase 6.0
Galina Gabriely et al. 2008 RP Nervous A172 N/A N/A
Location Method Result Regulation Validation Type Source
chr22:32860044-32861935 Luciferase Reporter Assay POSITIVE DIRECT TarBase 6.0
High-throughput experiments (0 positive, 1 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Galina Gabriely et al. 2008 MA N/A N/A N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Microarrays NEGATIVE INDIRECT TarBase 6.0
MAP2K3 hsa-miR-21-5p low: 6 high: 0 1 2 2 -
Low-throughput experiments (6 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Xu Guangxian et al. 2013 WB qP Liver HEPG2 N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Western Blot POSITIVE INDIRECT TarBase 7.0
UNKNOWN qPCR POSITIVE INDIRECT TarBase 7.0
Xu Guangxian et al. 2013 WB qP Kidney HEK293 N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Western Blot POSITIVE INDIRECT TarBase 7.0
UNKNOWN qPCR POSITIVE INDIRECT TarBase 7.0
Xu Guangxian et al. 2013 RP Liver HEPG2 HEPG2 N/A
Location Method Result Regulation Validation Type Source
chr17:21312151-21314697 Luciferase Reporter Assay POSITIVE DIRECT TarBase 7.0
Xu Guangxian et al. 2013 RP Kidney HEK293 HEPG2 N/A
Location Method Result Regulation Validation Type Source
chr17:21312151-21314697 Luciferase Reporter Assay POSITIVE DIRECT TarBase 7.0
DOCK5 hsa-miR-21-5p low: 6 high: 0 1 1 1 -
Low-throughput experiments (3 positive, 3 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Hara Kang et al. 2012 RP RP Kidney COS7 N/A N/A
Location Method Result Regulation Validation Type Source
chr8:25411954-25411975 Luciferase Reporter Assay POSITIVE DIRECT TarBase 7.0
chr8:25411310-25412234 Luciferase Reporter Assay POSITIVE DIRECT TarBase 7.0
chr8:25411799-25411821 Luciferase Reporter Assay POSITIVE DIRECT TarBase 7.0
chr8:25411570-25411591 Luciferase Reporter Assay NEGATIVE DIRECT TarBase 7.0
chr8:25412145-25412166 Luciferase Reporter Assay NEGATIVE DIRECT TarBase 7.0
chr8:25411584-25411606 Luciferase Reporter Assay NEGATIVE DIRECT TarBase 7.0
TGFBR2 hsa-miR-21-5p low: 5 high: 4 6 7 6 -
Low-throughput experiments (5 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Thales Papagiannakopoulos et al. 2008 RP Brain U251 U251 N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Luciferase Reporter Assay POSITIVE DIRECT TarBase 8.0
Yingjie Yu et al. 2012 WB qP Intestine HCT116 N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Western Blot POSITIVE INDIRECT TarBase 7.0
UNKNOWN qPCR POSITIVE INDIRECT TarBase 7.0
Yingjie Yu et al. 2012 RP Intestine HCT116 HCT116 N/A
Location Method Result Regulation Validation Type Source
chr3:30691790-30691812 Luciferase Reporter Assay POSITIVE DIRECT TarBase 7.0
Yeon Jeong Kim et al. 2009 RP Adipose HASC HASC N/A
Location Method Result Regulation Validation Type Source
chr3:30691790-30691812 Luciferase Reporter Assay POSITIVE DIRECT TarBase 6.0
High-throughput experiments (4 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Inna Lipchina et al. 2011 IP Embryo ESC N/A T1 RNase treatment
Location Method Result Regulation Validation Type Source
chr3:30693432-30693447 PAR-CLIP POSITIVE DIRECT TarBase 7.0
Galina Gabriely et al. 2008 MA N/A N/A N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Microarrays POSITIVE INDIRECT TarBase 6.0
Balakrishnan I et al. 2014 IP Bone Marrow HS5 N/A N/A
Location Method Result Regulation Validation Type Source
chr3:30691789-30691812 HITS-CLIP POSITIVE DIRECT TarBase 7.0
Balakrishnan I et al. 2014 IP Bone Marrow HS27A N/A N/A
Location Method Result Regulation Validation Type Source
chr3:30691789-30691812 HITS-CLIP POSITIVE DIRECT TarBase 7.0
DOCK7 hsa-miR-21-5p low: 5 high: 0 1 2 2 -
Low-throughput experiments (4 positive, 1 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Hara Kang et al. 2012 WB qP Pulmonary Artery PASMC N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Western Blot POSITIVE INDIRECT TarBase 7.0
UNKNOWN qPCR POSITIVE INDIRECT TarBase 7.0
Hara Kang et al. 2012 RP RP Kidney COS7 N/A N/A
Location Method Result Regulation Validation Type Source
chr1:62455349-62455371 Luciferase Reporter Assay POSITIVE DIRECT TarBase 7.0
chr1:62454755-62455413 Luciferase Reporter Assay POSITIVE DIRECT TarBase 7.0
chr1:62455213-62455235 Luciferase Reporter Assay NEGATIVE DIRECT TarBase 7.0
PDCD4 hsa-miR-21-5p low: 4 high: 7 10 9 7 -
Low-throughput experiments (4 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Fei E Wang et al. 2010 RP Eye N/A HEK293 N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Luciferase Reporter Assay POSITIVE DIRECT TarBase 8.0
Yi Yang et al. 2009 RP Mammary Gland MCF7 MCF7 N/A
Location Method Result Regulation Validation Type Source
chr10:110898109-110898691 Luciferase Reporter Assay POSITIVE DIRECT TarBase 8.0
Thales Papagiannakopoulos et al. 2008 RP Brain U251 U251 N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Luciferase Reporter Assay POSITIVE DIRECT TarBase 8.0
Zhou L. et al. 2013 RP Liver HCC Cell Lines HCC Cell Lines N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Luciferase Reporter Assay POSITIVE DIRECT TarBase 8.0
High-throughput experiments (7 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Pillai MM et al. 2014 IP Mammary Gland MCF7 N/A N/A
Location Method Result Regulation Validation Type Source
chr10:110898317-110898337 HITS-CLIP POSITIVE DIRECT TarBase 7.0
Pillai MM et al. 2014 IP Mammary Gland BT474 N/A N/A
Location Method Result Regulation Validation Type Source
chr10:110898455-110898483 HITS-CLIP POSITIVE DIRECT TarBase 7.0
Kishore S et al. 2011 IP Kidney HEK293 N/A mild MNase digestion
Location Method Result Regulation Validation Type Source
chr10:110898317-110898337 PAR-CLIP POSITIVE DIRECT TarBase 7.0
Karginov FV et al. 2013 IP Kidney 293S N/A treatment: arsenite
Location Method Result Regulation Validation Type Source
chr10:110898317-110898337 HITS-CLIP POSITIVE DIRECT TarBase 7.0
Haecker Irina et al. 2012 IP Bone Marrow BCBL1 N/A N/A
Location Method Result Regulation Validation Type Source
chr10:110898317-110898337 HITS-CLIP POSITIVE DIRECT TarBase 7.0
Eva Gottwein et al. 2011 IP Pleura BC1 N/A N/A
Location Method Result Regulation Validation Type Source
chr10:110898317-110898337 PAR-CLIP POSITIVE DIRECT TarBase 7.0
Farazi Thalia A et al. 2014 IP Mammary Gland MCF7 N/A N/A
Location Method Result Regulation Validation Type Source
chr10:110898317-110898337 PAR-CLIP POSITIVE DIRECT TarBase 7.0
IL1B hsa-miR-21-5p low: 4 high: 1 2 3 2 0.668
Low-throughput experiments (4 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Mineko Terao et al. 2011 qP RP Mammary Gland MDAMB231 HEK293T N/A
Location Method Result Regulation Validation Type Source
UNKNOWN qPCR POSITIVE INDIRECT TarBase 7.0
chr2:112829789-112830336 Luciferase Reporter Assay POSITIVE DIRECT TarBase 7.0
Mineko Terao et al. 2011 qP RP Mammary Gland MCF7 HEK293T N/A
Location Method Result Regulation Validation Type Source
UNKNOWN qPCR POSITIVE INDIRECT TarBase 7.0
chr2:112829789-112830336 Luciferase Reporter Assay POSITIVE DIRECT TarBase 7.0
High-throughput experiments (1 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Balakrishnan I et al. 2014 IP Bone Marrow HS5 N/A N/A
Location Method Result Regulation Validation Type Source
chr2:112829838-112829865 HITS-CLIP POSITIVE DIRECT TarBase 7.0
SERPINB5 hsa-miR-21-5p low: 4 high: 1 4 3 2 -
Low-throughput experiments (3 positive, 1 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Yi Yang et al. 2009 RP Mammary Gland MCF7 MCF7 N/A
Location Method Result Regulation Validation Type Source
chr18:63503746-63505023 Luciferase Reporter Assay NEGATIVE DIRECT TarBase 8.0
Shuomin Zhu et al. 2008 RP Mammary Gland MDAMB231 N/A N/A
Location Method Result Regulation Validation Type Source
chr18:63504887-63504908 Luciferase Reporter Assay POSITIVE DIRECT TarBase 6.0
Mineko Terao et al. 2011 RP Mammary Gland MDAMB231 HEK293T N/A
Location Method Result Regulation Validation Type Source
chr18:63503747-63505054 Luciferase Reporter Assay POSITIVE DIRECT TarBase 7.0
Mineko Terao et al. 2011 RP Mammary Gland MCF7 HEK293T N/A
Location Method Result Regulation Validation Type Source
chr18:63503747-63505054 Luciferase Reporter Assay POSITIVE DIRECT TarBase 7.0
High-throughput experiments (1 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Qian Xiong et al. 2012 PR Peripheral Blood U266 N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN SILAC POSITIVE INDIRECT TarBase 7.0
ICAM1 hsa-miR-21-5p low: 4 high: 0 1 2 1 -
Low-throughput experiments (4 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Mineko Terao et al. 2011 qP RP Mammary Gland MDAMB231 HEK293T N/A
Location Method Result Regulation Validation Type Source
UNKNOWN qPCR POSITIVE INDIRECT TarBase 7.0
chr19:10285280-10286591 Luciferase Reporter Assay POSITIVE DIRECT TarBase 7.0
Mineko Terao et al. 2011 qP RP Mammary Gland MCF7 HEK293T N/A
Location Method Result Regulation Validation Type Source
UNKNOWN qPCR POSITIVE INDIRECT TarBase 7.0
chr19:10285280-10286591 Luciferase Reporter Assay POSITIVE DIRECT TarBase 7.0
FASLG hsa-miR-21-5p low: 4 high: 0 1 2 1 0.979
Low-throughput experiments (4 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Na Wang et al. 2013 WB Esophagus EC9706 N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Western Blot POSITIVE INDIRECT TarBase 7.0
Na Wang et al. 2013 WB Esophagus EC1 N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Western Blot POSITIVE INDIRECT TarBase 7.0
Na Wang et al. 2013 RP Esophagus EC9706 EC9706 N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Luciferase Reporter Assay POSITIVE DIRECT TarBase 7.0
Na Wang et al. 2013 RP Esophagus EC1 EC1 N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Luciferase Reporter Assay POSITIVE DIRECT TarBase 7.0
PLAT hsa-miR-21-5p low: 4 high: 0 1 2 1 -
Low-throughput experiments (4 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Mineko Terao et al. 2011 qP RP Mammary Gland MDAMB231 HEK293T N/A
Location Method Result Regulation Validation Type Source
UNKNOWN qPCR POSITIVE INDIRECT TarBase 7.0
chr8:42174744-42175968 Luciferase Reporter Assay POSITIVE DIRECT TarBase 7.0
Mineko Terao et al. 2011 qP RP Mammary Gland MCF7 HEK293T N/A
Location Method Result Regulation Validation Type Source
UNKNOWN qPCR POSITIVE INDIRECT TarBase 7.0
chr8:42174744-42175968 Luciferase Reporter Assay POSITIVE DIRECT TarBase 7.0
PCBP1 hsa-miR-21-5p low: 3 high: 4 4 4 4 0.815
Low-throughput experiments (2 positive, 1 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Qian Xiong et al. 2012 RP Peripheral Blood U266 U266 N/A
Location Method Result Regulation Validation Type Source
chr2:70088991-70089013 Luciferase Reporter Assay POSITIVE DIRECT TarBase 7.0
Qian Xiong et al. 2012 WB qP Peripheral Blood U266 N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Western Blot POSITIVE INDIRECT TarBase 7.0
UNKNOWN qPCR NEGATIVE INDIRECT TarBase 7.0
High-throughput experiments (4 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Whisnant Adam W et al. 2013 IP Cervix TZMBL N/A shRNAs against HIV-1
Location Method Result Regulation Validation Type Source
chr2:70088990-70089012 PAR-CLIP POSITIVE DIRECT TarBase 7.0
Qian Xiong et al. 2012 PR Peripheral Blood U266 N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN SILAC POSITIVE INDIRECT TarBase 7.0
Pillai MM et al. 2014 IP Mammary Gland BT474 N/A N/A
Location Method Result Regulation Validation Type Source
chr2:70088990-70089012 HITS-CLIP POSITIVE DIRECT TarBase 7.0
Eva Gottwein et al. 2011 IP Pleura BC3 N/A N/A
Location Method Result Regulation Validation Type Source
chr2:70088990-70089012 PAR-CLIP POSITIVE DIRECT TarBase 7.0
CUL2 hsa-miR-21-5p low: 3 high: 1 1 1 1 -
Low-throughput experiments (1 positive, 2 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Qian Xiong et al. 2012 RP Peripheral Blood U266 U266 N/A
Location Method Result Regulation Validation Type Source
chr10:35009931-35009950 Luciferase Reporter Assay NEGATIVE DIRECT TarBase 7.0
Qian Xiong et al. 2012 WB qP Peripheral Blood U266 N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Western Blot POSITIVE INDIRECT TarBase 7.0
UNKNOWN qPCR NEGATIVE INDIRECT TarBase 7.0
High-throughput experiments (1 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Qian Xiong et al. 2012 PR Peripheral Blood U266 N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN SILAC POSITIVE INDIRECT TarBase 7.0
PIAS3 hsa-miR-21-5p low: 3 high: 1 1 1 1 -
Low-throughput experiments (2 positive, 1 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Qian Xiong et al. 2012 RP Peripheral Blood U266 U266 N/A
Location Method Result Regulation Validation Type Source
chr1:145848713-145848734 Luciferase Reporter Assay POSITIVE DIRECT TarBase 7.0
Qian Xiong et al. 2012 WB qP Peripheral Blood U266 N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN Western Blot POSITIVE INDIRECT TarBase 7.0
UNKNOWN qPCR NEGATIVE INDIRECT TarBase 7.0
High-throughput experiments (1 positive, 0 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Qian Xiong et al. 2012 PR Peripheral Blood U266 N/A N/A
Location Method Result Regulation Validation Type Source
UNKNOWN SILAC POSITIVE INDIRECT TarBase 7.0
CAPN2 hsa-miR-21-5p low: 3 high: 1 1 1 1 0.574
Low-throughput experiments (1 positive, 2 negative)
Publication Methods Tissue Cell line Tested cell line Exp. condition
Qian Xiong et al. 2012 RP Peripheral Blood U266 U266 N/A